Folic Acid, Asprin Medical Response Essay Examples & Outline
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Folic Acid, Asprin Medical Response
Deficiency in vitamin B12 and folic acid contributes to megaloblastic anemia, a condition where the red blood cells are larger than their normal. Megaloblastic anemia manifests with symptoms such as hyperactive reflexes, ataxia and peripheral neuropathy among others. Both folate and vitamin B12 play a crucial role in DNA synthesis (Olson, 2012). Replacement therapy has been used to treat deficiency of vitamin B12 and folic acid. This can be done both orally and intravenously. It should have been appropriate to mention dietary supplements that are rich in both vitamin B12 and folate. Furthermore, there is not mention of the role of vitamin B12 and folate in cellular metabolism.
Anemia that arises from the deficiency of folic acid and Vitamin B12 is known as macrocytic/megaloblastic (Katzung, Masters, & Trevor, 2012). In addition, both vitamins play a crucial role in DNA synthesis. Dietary vitamin B12 needs to be converted to its active form to enable effective utilization. It would have been a sufficient explanation of the pathway that converts vitamin B12 to the active form. Folic acid exists in both active and inactive form (Katzung, Masters, & Trevor, 2012). Dietary measures form the main approach of treating folic acid deficiency. Example of food that is rich in both vitamin B12 and folate include legumes, whole grain and fresh green vegetables. Oral supplementations, IM and subcutaneous injection of cyanocobalamin help in treating Vitamin B12 deficiency. Intranasal variants are available for individuals who cannot tolerate the two approaches.
Excellent work done but it would have been better to distinguish the mechanism of action between aspirin, heparin and warfarin as primary anticoagulants. Aspirin as an NSAID is administered to prevent platelet aggregation. It has inhibitory effects on cyclooxygenase in both platelets and endothelial cells. Heparin prevents formation of new clots with no effect on the existing one. Warfarin acts by blocking vitamin K binding sites. It acts on existing clots thus preventing their extension (Katzung, Masters, & Trevor, 2012). Clopidogrel is a drug that helps in preventing stroke. It is administered with warfarin to prevent ischemia and unstable angina. The major side effect of warfarin is internal bleeding. It may also cause birth defects and abortion, therefore, not appropriate for use by pregnant women. Furthermore, there is no mention of the side effects associated with the medications.
Aspirin has an inhibitory effect on COX. Clinical use of aspirin helps to treat transient ischemic attacks, MI and thrombosis. Aspirin is also used as a pain reliever due to its anti-inflammatory action by inhibiting prostaglandins